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Aspects of steroid metabolism in the normal and neoplastic mammary gland of the bitch

d'Arville, C. N., Evans, Bronwen Alice James, Borthwick, G. and Pierrepoint, C. G. 1980. Aspects of steroid metabolism in the normal and neoplastic mammary gland of the bitch. Journal of Steroid Biochemistry 13 (12) , pp. 1407-1411. 10.1016/0022-4731(80)90051-5

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Abstract

Normal and neoplastic canine mammary tissues have been incubated with radio-labelled progesterone, testosterone and androstenedione and metabolites isolated. In both tissues the most active enzyme demonstrated was 5α-reductase. Testosterone was converted to the more active androgen 5α-dihydrotes-tosterone only in the tumours. A reversal of the 3β-hydroxysteroid Δ4−5 isomerase enzyme system was noted without the addition of cofactors. Epitestosterone was formed from both testosterone and andros-tenedione in the tumours only.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 0022-4731
Last Modified: 04 Jun 2017 06:52
URI: http://orca.cf.ac.uk/id/eprint/65801

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