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Relative rates of degradation of mouse-liver surface-membrane proteins

Gurd, James W. and Evans, William Howard 1973. Relative rates of degradation of mouse-liver surface-membrane proteins. European Journal of Biochemistry 36 (1) , pp. 273-279. 10.1111/j.1432-1033.1973.tb02910.x

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Abstract

1. The relative rates of degradation of the proteins of liver membranes and soluble fractions were examined by using a double-isotope labelling technique. 2. The proteins of plasma membrane and smooth microsomal fraction were more rapidly degraded than those of the mitochondrial and soluble fractions. 3. No great variation in the rates of degradation of the proteins of plasma membrane and microsomal subfractions was detected. The proteins of intercellular gap-junctions (nexuses) were degraded slowly. 4. Extraction of plasma membranes with aqueous and organic solvents and detergents indicated that fractions known to be enriched in glycoproteins underwent more rapid degradation.5The high molecular weight components of liver plasma membranes and derivative fractions were more rapidly degraded than those of low molecular weight. Since glycoproteins predominated amongst the high molecular weight components of plasma membranes, the functional significance of this finding is discussed.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Wiley
ISSN: 0014-2956
Last Modified: 17 Mar 2021 02:51
URI: http://orca.cf.ac.uk/id/eprint/65827

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