The application of the phosphoramidate ProTide approach confers micromolar potency against Hepatitis C virus on inactive agent 4 '-azidoinosine: Kinase bypass on a dual base/sugar modified nucleoside

McGuigan, Christopher ORCID: https://orcid.org/0000-0001-8409-710X, Daverio, F., Najera, I., Martin, J. A., Klumpp, K. and Smith, D. B. 2009. The application of the phosphoramidate ProTide approach confers micromolar potency against Hepatitis C virus on inactive agent 4 '-azidoinosine: Kinase bypass on a dual base/sugar modified nucleoside. Biorganic and Medicinal Chemistry Letters 19 (11) , pp. 3122-3124. 10.1016/j.bmcl.2009.03.138

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Abstract

Novel phosphoramidate ProTides derived from 4′-azidoinosine have been prepared and evaluated in the replicon assay against hepatitis C Virus (HCV). The parent nucleoside analogue is inactive in this assay, while the ProTides are active at low μM levels in some cases. This is a rare example of an inosine nucleoside analogue with potent antiviral activity and further supports the notion of ProTides as a drug discovery motif.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Systems Immunity Research Institute (SIURI)
Subjects:	R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords:	HCV; Protides; Nucleotides; Hepatitis C virus; Prodrugs; Antiviral
Publisher:	Elsevier
ISSN:	0960-894X
Last Modified:	17 Oct 2022 10:03
URI:	https://orca.cardiff.ac.uk/id/eprint/6639

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