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The application of the phosphoramidate ProTide approach confers micromolar potency against Hepatitis C virus on inactive agent 4 '-azidoinosine: Kinase bypass on a dual base/sugar modified nucleoside

McGuigan, Christopher, Daverio, F., Najera, I., Martin, J. A., Klumpp, K. and Smith, D. B. 2009. The application of the phosphoramidate ProTide approach confers micromolar potency against Hepatitis C virus on inactive agent 4 '-azidoinosine: Kinase bypass on a dual base/sugar modified nucleoside. Biorganic and Medicinal Chemistry Letters 19 (11) , pp. 3122-3124. 10.1016/j.bmcl.2009.03.138

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Abstract

Novel phosphoramidate ProTides derived from 4′-azidoinosine have been prepared and evaluated in the replicon assay against hepatitis C Virus (HCV). The parent nucleoside analogue is inactive in this assay, while the ProTides are active at low μM levels in some cases. This is a rare example of an inosine nucleoside analogue with potent antiviral activity and further supports the notion of ProTides as a drug discovery motif.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: HCV; Protides; Nucleotides; Hepatitis C virus; Prodrugs; Antiviral
Publisher: Elsevier
ISSN: 0960-894X
Last Modified: 18 Oct 2017 13:14
URI: http://orca.cf.ac.uk/id/eprint/6639

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