Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2AG-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer

Navarro, Gemma, Carriba, Paulina, Gandí, Jorge, Ciruela, Francisci, Casadó, Vicent, Cortés, Antoni, Mallol, Josefa, Canela, Enric I., Lluis, Carmen and Franco, Rafael 2008. Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2AG-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer. The Scientific World Journal 8 , pp. 1088-1097. 10.1100/tsw.2008.136

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Abstract

Functional interactions in signaling occur between dopamine D2 (D2R) and cannabinoid CB1 (CB1R) receptors, between CB1R and adenosine A2A (A2AR) receptors, and between D2R and A2AR. Furthermore, direct molecular interactions have been reported for the pairs CB1R-D2R, A2AR-D2R, and CB1R-A2AR. Here a combination of bimolecular fluorescence complementation and bioluminescence energy transfer techniques was used to identify the occurrence of D2R-CB1R-A2AR hetero-oligomers in living cells.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology
Publisher:	Scientific World
ISSN:	1537-744X
Last Modified:	17 Mar 2021 02:42
URI:	https://orca.cardiff.ac.uk/id/eprint/66909

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