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Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition

Pepper, C., Buggins, A. G.S., Jones, C. H., Walsby, E. J., Forconi, F., Pratt, G., Devereux, S., Stevenson, F. and Fegan, C. 2015. Phenotypic heterogeneity in IGHV-mutated CLL patients has prognostic impact and identifies a subset with increased sensitivity to BTK and PI3Kδ inhibition. Leukemia 29 , pp. 744-747. 10.1038/leu.2014.308

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Abstract

The majority of chronic lymphocytic leukemia (CLL) patients are diagnosed with early-stage disease but the currently used prognostic tools appear to be less informative in this group of patients.1 This is especially problematic for patients with mutated immunoglobulin genes (M-CLL) as they have a more diverse clinical course when compared with patients with unmutated immunoglobulin genes (U-CLL).1, 2, 3, 4 Given the emergence of promising targeted, less toxic, therapeutics in CLL,5, 6 there is an increased need to identify patients who might benefit from early treatment with these new agents.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Additional Information: This work is licensed under a Creative Commons Attribution 4.0 International License.
Publisher: Springer Nature
ISSN: 0887-6924
Funders: Leukaemia & Lymphoma Research, Leukaemia Research Appeal for Wales, NISCHR, Global CLL Research Foundation
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 20 October 2014
Last Modified: 09 Jun 2020 12:45
URI: http://orca.cf.ac.uk/id/eprint/67297

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