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Topical delivery of retinyl ascorbate co-drug: 6. determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes

Abdulmajed, Karim, McGuigan, Christopher and Heard, Charles Martin 2005. Topical delivery of retinyl ascorbate co-drug: 6. determination of toxic dose and antioxidant activity in cultured human epidermal keratinocytes. Die Pharmazie - An International Journal of Pharmaceutical Sciences, 60 (10) , pp. 794-795.

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Abstract

The maximum effective dose of retinyl ascorbate and its potential therapeutic benefits against induced oxidative damage were assessed in vitro using cultured human epidermal keratinocytes. RA-AsA exhibited toxic effects at concentrations >6 μM. The findings indicate to the potency of RA-AsA as free radical scavenger and cell proliferation regulator.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Ingenta Connect
ISSN: 0031-7144
Last Modified: 21 Oct 2017 06:25
URI: http://orca.cf.ac.uk/id/eprint/67449

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