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Enantiomeric resolution of some 2-arylpropionic acids using L(-)-serine-impregnated silica as stationary phase by thin layer chromatography

Aboul-Enein, H. Y., El-Awady, M. I. and Heard, Charles Martin 2003. Enantiomeric resolution of some 2-arylpropionic acids using L(-)-serine-impregnated silica as stationary phase by thin layer chromatography. Journal of Pharmaceutical and Biomedical Analysis 32 (4-5) , pp. 1055-1059. 10.1016/S0731-7085(03)00208-5

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Abstract

The enantiomeric resolution of certain 2-arylpropionic acids was achieved on thin silica gel plates impregnated with optically pure l-(−)-serine as chiral selector. The mobile phase enabling successful resolution of (±)-ibuproxam and (±)-ketoprofen was acetonitrile–methanol–water (16:4:0.5, v/v/v) and (16:3:0.5, v/v/v) for (±)-tiaprofenic acid. The spots were detected with iodine vapors and the detection limits were found to be different for each of the 2-arylpropionic acid, ranging between 0.25 and 0.50 μg/ml. The effect of concentration of the impregnating chiral selector, temperature and pH on resolution has been studied. The procedure was applied successfully to resolve commercial ampoules of ketoprofen dosage formulation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RS Pharmacy and materia medica
Publisher: Elsevier
ISSN: 0731-7085
Last Modified: 04 Jun 2017 07:44
URI: http://orca.cf.ac.uk/id/eprint/67493

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