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Invitro skin penetration of propranolol enantiomers

Heard, Charles Martin, Watkinson, A. C., Brain, Keith Roger and Hadgraft, J. 1993. Invitro skin penetration of propranolol enantiomers. International Journal of Pharmaceutics 90 (3) , R5-R8. 10.1016/0378-5173(93)90202-Q

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Abstract

Transfer rates of individual enantiomers of propranolol across human skin were determined in vitro. Percutaneous penetration of propranolol from propylene glycol was negligible at the concentration previously reported to show enantioselective transfer in rat skin. Transfer of (R)- and (S)-propranolol from aqueous solutions of both the racemate and the pure enantiomers showed no differences in the rates of penetration demonstrating that the rate of transfer of propranolol across human skin from these solutions was independent of the stereochemistry of the drug. In addition there was no evidence for racemisation during the transfer process.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Percutaneous penetration; Enantioselective transfer; Propranolol; Enantiomer; In vitro penetration.
Publisher: Elsevier
ISSN: 0378-5173
Last Modified: 20 Dec 2017 03:06
URI: http://orca.cf.ac.uk/id/eprint/67515

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