Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection

Newman, Daniel P., Cummins, Tarrant D. R., Tong, Janette H. S., Johnson, Beth P., Pickering, Hayley, Fanning, Peter, Wagner, Joseph, Goodrich, Jack T. T., Hawi, Ziarih, Chambers, Christopher D. and Bellgrove, Mark A. 2014. Dopamine transporter genotype is associated with a lateralized resistance to distraction during attention selection. Journal of Neuroscience 34 (47) , pp. 15743-15750. 10.1523/JNEUROSCI.2327-14.2014

PDF - Published Version
Download (645kB) | Preview


Although lateral asymmetries in orienting behavior are evident across species and have been linked to interhemispheric asymmetries in dopamine signaling, the relative contribution of attentional versus motoric processes remains unclear. Here we took a cognitive genetic approach to adjudicate between roles for dopamine in attentional versus response selection. A sample of nonclinical adult humans (N = 518) performed three cognitive tasks (spatial attentional competition, spatial cueing, and flanker tasks) that varied in the degree to which they required participants to resolve attentional or response competition. All participants were genotyped for two putatively functional tandem repeat polymorphisms of the dopamine transporter gene (DAT1; SLC6A3), which are argued to influence the level of available synaptic dopamine and confer risk to disorders of inattention. DAT1 genotype modulated the task-specific effects of the various task-irrelevant stimuli across both the spatial competition and spatial cueing but not flanker tasks. Specifically, compared with individuals carrying one or two copies of the 10-repeat DAT1 allele, individuals without this allele demonstrated an immunity to distraction, such that response times were unaffected by increases in the number of distractor stimuli, particularly when these were presented predominantly in the left hemifield. All three genotype groups exhibited uniform costs of resolving leftward response selection in a standard flanker task. None of these significant effects could be explained by speed–accuracy trade-offs, suggesting that participants without the 10-repeat allele of the DAT1 tandem repeat polymorphism possess an enhanced attentional ability to suppress task-irrelevant stimuli in the left hemifield.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Subjects: B Philosophy. Psychology. Religion > BF Psychology
Uncontrolled Keywords: DAT1; dopamine; genetics; individual differences; selective attention; spatial attention.
Additional Information: Pdf uploaded in accordance with the publisher’s policy at (accessed 21/11/2014)
Publisher: Society for Neuroscience
ISSN: 0270-6474
Funders: NHMRC, ARC
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 07:45

Citation Data

Cited 10 times in Google Scholar. View in Google Scholar

Cited 7 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics