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Precise control of plant stem cell activity through parallel regulatory inputs

Bennett, T., van den Toorn, A., Willemsen, V. and Scheres, Ben 2014. Precise control of plant stem cell activity through parallel regulatory inputs. Development 141 (21) , pp. 4055-4064. 10.1242/dev.110148

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Abstract

The regulation of columella stem cell activity in the Arabidopsis root cap by a nearby organizing centre, the quiescent centre, has been a key example of the stem cell niche paradigm in plants. Here, we investigate interactions between transcription factors that have been shown to regulate columella stem cells using a simple quantification method for stem cell activity in the root cap. Genetic and expression analyses reveal that the RETINOBLASTOMA-RELATED protein, the FEZ and SOMBRERO NAC-domain transcription factors, the ARF10 and ARF16 auxin response factors and the quiescent centre-expressed WOX5 homeodomain protein each provide independent inputs to regulate the number of columella stem cells. Given the tight control of columella development, we found that these inputs act in a surprisingly parallel manner. Nevertheless, important points of interaction exist; for example, we demonstrate the repression of SMB activity by non-autonomous action of WOX5. Our results suggest that the developmental progression of columella stem cells may be quantitatively regulated by several more broadly acting transcription factors rather than by a single intrinsic stem cell factor, which raises questions about the special nature of the stem cell state in plants.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Company of Biologists
ISSN: 0950-1991
Last Modified: 20 Feb 2019 13:52
URI: http://orca.cf.ac.uk/id/eprint/68318

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