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3D bioprinting of carboxymethylated-periodate oxidized nanocellulose constructs for wound dressing applications

Rees, Adam, Powell, Lydia C., Chinga-Carrasco, Gary, Gethin, David T., Syverud, Kristin, Hill, Katja E. and Thomas, David William 2015. 3D bioprinting of carboxymethylated-periodate oxidized nanocellulose constructs for wound dressing applications. BioMedical Research International 2015 , pp. 1-7. 10.1155/2015/925757

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Abstract

Nanocellulose has a variety of advantages, which make the material most suitable for use in biomedical devices such as wound dressings. The material is strong, allows for production of transparent films, provides a moist wound healing environment, and can form elastic gels with bioresponsive characteristics. In this study, we explore the application of nanocellulose as a bioink for modifying film surfaces by a bioprinting process. Two different nanocelluloses were used, prepared with TEMPO mediated oxidation and a combination of carboxymethylation and periodate oxidation. The combination of carboxymethylation and periodate oxidation produced a homogeneous material with short nanofibrils, having widths <20 nm and lengths <200 nm. The small dimensions of the nanofibrils reduced the viscosity of the nanocellulose, thus yielding a material with good rheological properties for use as a bioink. The nanocellulose bioink was thus used for printing 3D porous structures, which is exemplified in this study. We also demonstrated that both nanocelluloses did not support bacterial growth, which is an interesting property of these novel materials.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > RK Dentistry
Publisher: BioMed Research International
Date of Acceptance: 30 September 2014
Last Modified: 21 Dec 2017 19:55
URI: http://orca.cf.ac.uk/id/eprint/68330

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Cited 2 times in Web of Science. View in Web of Science.

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