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A regulatory component of the human ryanodine receptor 2 N-terminus

Borko, Lubomir, Bauerova-Hlinkova, Vladena, Zahradnikova, Alexandra, Kostan, Julius, Beck, Konrad, Gasperik, Juraj, Hostinova, Eva, Lai, Francis Anthony and Sevcik, Jozef 2014. A regulatory component of the human ryanodine receptor 2 N-terminus. Biophysical Journal 106 (2) , 107A-107A. 10.1016/j.bpj.2013.11.661

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Human cardiac ryanodine receptor (hRyR2) is a channel mediating Ca2+ release from the sarcoplasmic reticulum during excitation-contraction coupling. The N-terminal (1-655) and central (2100-2500) regions of hRyR2 are thought to be involved in regulating channel gating. Mutations linked to several heart diseases are clustered within these two, as well as in the channel pore-containing C-terminal regions. High resolution structures of key regions involved in the regulation of RyR2 activity could further the understanding of the gating mechanism of hRyR2 and of its malfunction in disease.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Biosciences
Additional Information: Pdf uploaded in accordance with publisher's policies at (accessed 19.12.14).
Publisher: Biophysical Society
ISSN: 0006-3495
Last Modified: 27 Mar 2020 02:39

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