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Collagen structure and mechanical properties of the human sclera: Analysis for the effects of age

Coudrillier, Baptiste, Pijanka, Jacek K., Jefferys, Joan, Sorensen, Thomas, Quigley, Harry A., Boote, Craig and Nguyen, Thao D. 2015. Collagen structure and mechanical properties of the human sclera: Analysis for the effects of age. Journal of Biomechanical Engineering 137 (4) , BIO-14-1028. 10.1115/1.4029430

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Abstract

The objective of this study was to measure the collagen fiber structure and estimate the material properties of 7 human donor scleras, from age 53 to 91. The specimens were subjected to inflation testing, and the full-field displacement maps were measured by digital image correlation (DIC). After testing, the collagen fiber structure was mapped using wide-angle x-ray scattering (WAXS). A specimen-specific inverse finite element method was applied to calculate the material properties of the collagen fibers and inter-fiber matrix by minimizing the difference between the experimental displacements and model predictions. Age effects on the fiber structure and material properties were estimated using multivariate models accounting for spatial autocorrelation. Older age was associated with a larger matrix stiffness (p=0.001), a lower degree of fiber alignment in the peripapillary sclera (p=0.01), and a lower mechanical anisotropy in the peripapillary sclera (p=0.03)

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Publisher: ASME
ISSN: 0148-0731
Last Modified: 19 Mar 2019 22:34
URI: http://orca.cf.ac.uk/id/eprint/68703

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