Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The impact of regulatory T cells on carcinogen-induced sarcogenesis

Betts, G., Twohig, Jason Peter, Van den Broek, M., Sierro, S., Godkin, Andrew James and Gallimore, Awen Myfanwy 2007. The impact of regulatory T cells on carcinogen-induced sarcogenesis. British Journal of Cancer 96 (12) , pp. 1849-1854. 10.1038/sj.bjc.6603824

Full text not available from this repository.

Abstract

Burnet proposed in the 1950's that the immune system is engaged in identifying and destroying abnormal cancerous cells. This process, termed immune surveillance, has been at the centre of intense debate for decades. Results using immunodeficient mice lend support to the immune surveillance hypothesis. We surmised that immune surveillance would be hampered by the inhibitory effect of naturally occurring FoxP3+ regulatory T cells, a population of T cells shown to be present at an increased frequency in a variety of human tumours. The carcinogen, methylcholanthrene was injected subcutaneously into mice and the steady development of fibrosarcomas was observed over approximately 200 days. These fibrosarcomas were strikingly infiltrated with FoxP3+ regulatory T cells implying that these cells impinge upon immune-mediated rejection of the tumour. This was confirmed by partial ablation of FoxP3+ regulatory T-cell activity, which resulted in a marked reduction in tumour incidence. The reduction of tumour incidence was ablated in mice that lacked interferon gamma. These data offer strong support for the concept of immune surveillance and indicate that this process is limited by the inhibitory effect of FoxP3+ regulatory T cells.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Publisher: Nature Publishing Group
ISSN: 0007-0920
Last Modified: 21 Dec 2017 20:08
URI: http://orca.cf.ac.uk/id/eprint/68891

Citation Data

Cited 52 times in Google Scholar. View in Google Scholar

Cited 56 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 43 times in Web of Science. View in Web of Science.

Actions (repository staff only)

Edit Item Edit Item