Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Interactions between mammalian cells and nano- or micro-sized wear particles: Physico-chemical views against biological approaches

Prokopovich, Polina 2014. Interactions between mammalian cells and nano- or micro-sized wear particles: Physico-chemical views against biological approaches. Advances in Colloid and Interface Science 213 , pp. 36-47. 10.1016/j.cis.2014.09.001

[img]
Preview
PDF - Accepted Post-Print Version
Download (884kB) | Preview

Abstract

Total joint arthroplasty (TJA) is a more and more frequent approach for the treatment of end-stage osteoarthritis in young and active adults; it successfully relieves joint pain and improves function significantly enhancing the health-related quality of life. Aseptic loosening and other wear-related complications are some of the most recurrent reasons for revision of TJA. This review focuses on current understanding of the biological reactions to prosthetic wear debris comparing in vivo and in vitro results. Mechanisms of interactions of various types of cells with metal, polymeric and ceramic wear particles are summarised. Alternative views based on multidisciplinary approaches are proposed to consider physico-chemical, surface parameters of wear particles (such as: particle size, geometry and charge) and material (particle chemical composition and its nature) with biological effects (cellular responses).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Wear debris; Biological reactions; Nanotoxicity; Morphology; TJR
Publisher: Elsevier
ISSN: 0001-8686
Date of First Compliant Deposit: 30 March 2016
Last Modified: 01 Mar 2019 15:29
URI: http://orca.cf.ac.uk/id/eprint/69383

Citation Data

Cited 24 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics