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Identifying progenitor cells within articular cartilage

Richardson, Kirsty, Khan, I. M. and Archer, Charles W. 2006. Identifying progenitor cells within articular cartilage. European Cells and Materials 12 (Supp 1) , p. 70.

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Previous studies have shown that articular cartilage grows by apposition from the articular surface driven by proliferation of a progenitor cell sub-population that resides in the surface zone. This study concentrates on identifying markers for this progenitor cell population. Cell surface receptors CD105 and CD166 are known markers of progenitor/stem cells in endothelial cells, bone marrow constituents as well as other tissues and have recently been reported within normal and osteoarthritc human articular cartilage 1,2. Notch 1, Delta and Jagged 1 and 2 are known to be expressed by stem/progenitor cells during various stages of limb development 3 . Localisation of these markers to progenitor cells in articular cartilage would enable selective isolation facilitating further characterisation of the chondroprogenitor.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: Q Science > QH Natural history > QH426 Genetics
Publisher: European Cells & Materials Ltd
ISSN: 1473-2262
Last Modified: 04 Jun 2017 07:53

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