Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Enhancer evolution across 20 mammalian species

Villar, Diego, Berthelot, Camille, Aldridge, Sarah, Rayner, Tim F., Lukk, Margus, Pignatelli, Miguel, Park, Thomas J., Deaville, Robert, Erichsen, Jonathan T., Jasinska, Anna J., Turner, James M.A., Bertelsen, Mads F., Murchison, Elizabeth P., Flicek, Paul and Odom, Duncan T. 2015. Enhancer evolution across 20 mammalian species. Cell 160 (3) , pp. 554-566. 10.1016/j.cell.2015.01.006

Full text not available from this repository.


The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and enhancers active in liver across 20 mammalian species from six diverse orders by profiling genomic enrichment of H3K27 acetylation and H3K4 trimethylation. We report that rapid evolution of enhancers is a universal feature of mammalian genomes. Most of the recently evolved enhancers arise from ancestral DNA exaptation, rather than lineage-specific expansions of repeat elements. In contrast, almost all liver promoters are partially or fully conserved across these species. Our data further reveal that recently evolved enhancers can be associated with genes under positive selection, demonstrating the power of this approach for annotating regulatory adaptations in genomic sequences. These results provide important insight into the functional genetics underpinning mammalian regulatory evolution.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Subjects: R Medicine > RE Ophthalmology
Additional Information: Open Access article funded by Wellcome Trust under a Creative Commons license.
Publisher: Elsevier (Cell Press)
ISSN: 0092-8674
Funders: Wellcome Trust
Date of Acceptance: 15 December 2014
Last Modified: 14 Feb 2020 11:30

Citation Data

Cited 283 times in Google Scholar. View in Google Scholar

Cited 186 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item