Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts

Vasen, Hans F. A., Blanco, Ignacio, Aktan-Collan, Katja, Gopie, Jessica P., Alonso, Angel, Aretz, Stefan, Bernstein, Inge, Bertario, Lucio, Burn, John, Capella, Gabriel, Colas, Chrystelle, Engel, Christoph, Frayling, Ian Martin, Genuardi, Maurizio, Heinimann, Karl, Hes, Frederik J., Hodgson, Shirley V., Karagiannis, John A., Lalloo, Fiona, Lindblom, Annika, Mecklin, Jukka-Pekka, Moller, Pal, Myrhoj, Torben, Nagengast, Fokko M., Parc, Yann, de Leon, Maurizio Ponz, Renkonen-Sinisalo, Laura, Sampson, Julian Roy, Stormorken, Astrid, Sijmons, Rolf H., Tejpar, Sabine, Thomas, Huw J. W., Rahner, Nils, Wijnen, Juul T., Jaervinen, Heikki Juhani and Moeslein, Gabriela 2013. Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Gut 62 (6) , pp. 812-823. 10.1136/gutjnl-2012-304356

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (297kB) | Preview

Abstract

Lynch syndrome (LS) is characterised by the development of colorectal cancer, endometrial cancer and various other cancers, and is caused by a mutation in one of the mismatch repair genes: MLH1, MSH2, MSH6 or PMS2. In 2007, a group of European experts (the Mallorca group) published guidelines for the clinical management of LS. Since then substantial new information has become available necessitating an update of the guidelines. In 2011 and 2012 workshops were organised in Palma de Mallorca. A total of 35 specialists from 13 countries participated in the meetings. The first step was to formulate important clinical questions. Then a systematic literature search was performed using the Pubmed database and manual searches of relevant articles. During the workshops the outcome of the literature search was discussed in detail. The guidelines described in this paper may be helpful for the appropriate management of families with LS. Prospective controlled studies should be undertaken to improve further the care of these families.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: BMJ Publishing Group
ISSN: 0017-5749
Date of First Compliant Deposit: 30 March 2016
Last Modified: 20 Dec 2017 00:36
URI: http://orca.cf.ac.uk/id/eprint/70062

Citation Data

Cited 488 times in Google Scholar. View in Google Scholar

Cited 372 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics