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A molecular epidemiological study of sequential oral isolates of Candida albicans from terminally ill patients

Wilson, Melanie, Williams, David Wynne, Forbes, M.D.L., Finlay, Ilora Gillian and Lewis, Michael Alexander Oxenham 2001. A molecular epidemiological study of sequential oral isolates of Candida albicans from terminally ill patients. Journal Of Oral Pathology & Medicine 30 (4) , pp. 206-212. 10.1034/j.1600-0714.2001.300403.x

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The pattern of candidal colonisation was studied in a group of terminally ill patients receiving antifungal treatment for oral candidosis. A total of 43 isolates of C. albicans was collected pre- and post-antifungal treatment from patients up to a maximum period of 4 weeks. Isolates were analysed by electrophoretic karyotyping (EK) and by inter-repeat polymerase chain reaction (IR-PCR). Fifteen electrophoretic karyotypes and 17 IR-PCR profiles were identified. Sequential isolates from 10 patients yielded identical profiles in both EKs and IR-PCR analyses. In the case of four patients, minor differences in the profiles were obtained by either EK or IR-PCR. The findings suggest that antifungal treatment in this patient group fails to eradicate the original C. albicans strain, thereby allowing recolonisation of the oral cavity. The present study has also shown that either EK or IR-PCR is a useful typing approach in such epidemiological investigations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Dentistry
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Candida ; molecular epidemiology ; oral candidosis ; typing
Publisher: Blackwell Publishing
ISSN: 1600-0714
Last Modified: 15 Dec 2017 08:34

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