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Prevalence of the APC E1317Q variant in colorectal cancer patients

Popat, Sanjay, Stone, Joanne, Coleman, Gary, Marshall, Gill, Peto, Julian, Frayling, Ian Martin and Houlston, Richard 2000. Prevalence of the APC E1317Q variant in colorectal cancer patients. Cancer Letters 149 (1-2) , pp. 203-206. 10.1016/S0304-3835(99)00360-2

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The notion that some common variants of APC might confer an increased colorectal tumour risk is supported by studies of the I1307K polymorphism. Recently it has been proposed that the E1317Q variant is also associated with an increased risk. We have studied the prevalence of E1317Q in 364 colorectal cancer patients and in 290 controls. Two patients were shown to possess E1317Q. Neither had a family history of colorectal cancer or co-existent adenomatous polyps. Two controls also carried E1317Q. This finding suggests that E1317Q is unlikely to be associated with anything more than a moderate increase in risk of colorectal cancer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Uncontrolled Keywords: Colorectal cancer; E1317Q; Adenomatous polyposis coli
Publisher: Elsevier
ISSN: 0304-3835
Last Modified: 04 Jun 2017 07:56

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