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The complement-inhibiting protein, protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells

Rooney, I. A., Davies, A., Griffiths, David Francis Rees, Williams, John David, Davies, M., Meri, S., Lachmann, P. J. and Morgan, B. P. 1991. The complement-inhibiting protein, protectin (CD59 antigen), is present and functionally active on glomerular epithelial cells. Clinical and Experimental Immunology 83 (2) , pp. 251-256. 10.1111/j.1365-2249.1991.tb05623.x

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Abstract

Protectin (CD59 antigen) is a 20-kD phosphatidyl-inositol-linked membrane protein that inhibits formation of the membrane attack complex (MAC) of complement on homologous cells. Although the antigen has been identified in a number of human tissues, until recently a functional role had been demonstrated only in circulating cells. Using immunofluorescence techniques we have shown the presence of protectin on human glomerular epithelial cells (GEC) in culture and on GEC, tubular epithelial cells and endothelial cells in frozen sections of normal human renal cortex. In addition, we present evidence that this protein functions in protection of GEC from homologous complement: cultured cells incubated with the Fab2 fragment of a monoclonal anti-protein antibody were markedly more susceptible to killing by homologous serum than were cells in the absence of Fab2 anti-protectin. These findings suggest that this protein may be important in the maintenance of glomerular integrity in vivo, and may be of relevance in certain renal diseases.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Wiley-Blackwell
ISSN: 0009-9104
Last Modified: 19 Jan 2019 23:01
URI: http://orca.cf.ac.uk/id/eprint/70318

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