Morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children

Hain, Richard D.W., Hardcastle, A., Pinkerton, C.R. and Aherne, G.W. 1999. Morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children. British Journal of Clinical Pharmacology 48 (1) , pp. 37-42. 10.1046/j.1365-2125.1999.00948.x

Full text not available from this repository.

Abstract

AIMS: To measure morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children following a single intravenous dose of morphine. METHODS: Twenty-nine paired samples of cerebrospinal fluid and plasma were collected from children with leukaemia undergoing therapeutic lumbar puncture. An intravenous dose of morphine was administered at selected intervals before the procedure. Concentrations of morphine and morphine-6-glucuronide (M6G) were measured in each sample. Morphine was measured using a specific radioimmunoassay (r.i.a.) and M6G was measured using a novel enzyme-linked immunosorbent assay (ELISA). RESULTS: The ELISA for measuring M6G was highly sensitive. The intra-and interassay variations were less than 15%. Using a two-compartment model for plasma morphine, the area under the curve to infinity (AUC, 7143 ng ml-1 min), volume of distribution (3.6 l kg-1 ) and elimination half-life (88 min) were comparable with those reported in adults. Clearance (35 ml min-1 ) was higher than that in adults. Morphine-6-glucuronide was readily synthesized by the children in this study. The elimination half-life (321 min) and AUC (35507 ng ml-1 min) of plasma M6G were much greater than those of morphine. CONCLUSIONS: Extensive metabolism of morphine to M6G in children with cancer has been demonstrated. These data provide further evidence to support the importance of M6G accumulation after multiple doses. There was no evidence that morphine passed more easily into the CSF of children than adults.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Subjects:	R Medicine > RJ Pediatrics R Medicine > RM Therapeutics. Pharmacology
Additional Information:	Full Text Sources Blackwell Publishing EBSCO Ovid Technologies, Inc. PubMed Central Other Literature Sources Access more work from the authors - ResearchGate Molecular Biology Databases MORPHINE - HSDB
Publisher:	Wiley-Blackwell
ISSN:	0306-5251
Last Modified:	02 Nov 2015 10:05
URI:	https://orca.cardiff.ac.uk/id/eprint/70576

Citation Data

Cited 38 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item