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In search of the acute oxygen sensor: Functional proteomics and acute regulation of large-conductance, calcium-activated potassium channels by hemeoxygenase-2

Kemp, Paul J., Peers, Chris, Riccardi, Daniela, Iles, David E., Mason, Helen S., Wootton, Philippa and Williams, Sandile E. 2006. In search of the acute oxygen sensor: Functional proteomics and acute regulation of large-conductance, calcium-activated potassium channels by hemeoxygenase-2. In: Hayashida, Yoshiaki, Gonzalez, Constancio and Kondo, Hisatake eds. The Arterial Chemoreceptors, Vol. 580. Advances in Experimental Medicine and Biology, Springer, pp. 137-146. (10.1007/0-387-31311-7_21)

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Abstract

Detecting and reacting to acute perturbation in the partial pressure of atmospheric oxygen (pO2), particularly hypoxia, is a fundamental adaptive mechanism which is conserved throughout the animal kingdom. In mammals, a number of cellular systems respond, often co-operatively as oxygen availability becomes compromised, with the express aim of maximising oxygen uptake by the lungs and of optimising its delivery to the metabolically most active tissues. Thus, during hypoxia, ventilation rate and depth are increased to maximize air flow across the gaseous exchange surface, local lung perfusion rates become rapidly matched to local alveolar ventilation and systemic arteriolar dilatation ensures that tissue and cerebral blood flow become swiftly optimized.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QP Physiology
Q Science > QR Microbiology
Publisher: Springer
Last Modified: 04 Jun 2017 07:59
URI: http://orca.cf.ac.uk/id/eprint/71235

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Cited 2 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 2 times in Web of Science. View in Web of Science.

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