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Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events

Goodwin, Naomi, Strong, P. J., Sudhir, G., Wilkes, A. R. and Hall, Judith Elizabeth 2005. Effect of breathing low concentrations of volatile anaesthetic agents on incidence of adverse airway events. Anaesthesia -London- 60 (10) , pp. 955-959. 10.1111/j.1365-2044.2005.04279.x

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Abstract

The effect of breathing 0.1 minimum alveolar concentrations (MAC) of desflurane or isoflurane for three minutes on the incidence of adverse airway events on a subsequent breath of 2 MAC was investigated. Twenty-five volunteers known to develop an adverse airway event to desflurane or isoflurane took part in the study. Each volunteer was exposed to isoflurane and desflurane at least 24 h apart. Volunteers were assessed for adverse airway events while breathing 2 MAC inhalational anaesthetic following breathing 100% O(2) for 3 min. This was repeated with 0.1 MAC inhalational anaesthetic in oxygen instead of 100% O(2). Adverse airway events decreased from 88% to 40% when tests were conducted with desflurane (p = 0.002). With isoflurane, the reduction from 60% to 52% was not statistically significant (p = 0.774). Breathing low concentrations of desflurane decreases the incidence of adverse airway events on subsequent inhalation of higher concentration of desflurane.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Publisher: Wiley-Blackwell
ISSN: 0003-2409
Last Modified: 19 May 2019 23:23
URI: http://orca.cf.ac.uk/id/eprint/71306

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