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Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine

Osborne, C. S., Leitner, I., Hofbauer, B., Fielding, Ceri Alan, Favre, B. and Ryder, N. S. 2006. Biological, biochemical, and molecular characterization of a new clinical Trichophyton rubrum isolate resistant to terbinafine. Antimicrobial Agents and Chemotherapy 50 (6) , pp. 2234-2236. 10.1128/AAC.01600-05

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Abstract

We have characterized a new clinical strain of Trichophyton rubrum highly resistant to terbinafine but exhibiting normal susceptibility to drugs with other mechanisms of action. Resistance to terbinafine in this strain is caused by a missense mutation in the squalene epoxidase gene leading to the amino acid substitution F397L.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: American Society for Microbiology
ISSN: 0066-4804
Last Modified: 04 Jun 2017 08:00
URI: http://orca.cf.ac.uk/id/eprint/71415

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