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Mouse models of Huntington's disease

Brooks, Simon Philip and Dunnett, Stephen Bruce 2015. Mouse models of Huntington's disease. Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease, Current Topics in Behavioral Neurosciences, vol. 22. Berlin: Springer, pp. 101-133. (10.1007/7854_2013_256)

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Abstract

In this review, we explore the similarities and differences in the behavioural neurobiology found in the mouse models of Huntington’s disease (HD) and the human disease state. The review is organised with a comparative focus on the functional domains of motor control, cognition and behavioural disturbance (akin to psychiatric disturbance in people) and how our knowledge of the underlying physiological changes that are manifest in the HD mouse lines correspond to those seen in the HD clinical population. The review is framed in terms of functional circuitry and neurotransmitter systems and how abnormalities in these systems impact on the behavioural readouts across the mouse lines and how these may correspond to the deficits observed in people. In addition, interpretational issues associated with the data from animal studies are discussed.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: Q Science > QR Microbiology
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Springer
ISBN: 9783662463437
Last Modified: 04 Jun 2017 08:01
URI: http://orca.cf.ac.uk/id/eprint/71733

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