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Fate-restricted neural progenitors in the mammalian cerebral cortex

Franco, S. J., Gil-Sanz, C., Martinez Garay, Isabel, Espinosa, A., Harkins-Perry, S. R., Ramos, C. and Muller, U. 2012. Fate-restricted neural progenitors in the mammalian cerebral cortex. Science 337 (6095) , pp. 746-749. 10.1126/science.1223616

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Abstract

During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by birthdate through progressive restriction of the neurogenic potential of a common RGC progenitor. Here, we demonstrate that the murine cerebral cortex contains RGC sublineages with distinct fate potentials. Using in vivo genetic fate mapping and in vitro clonal analysis, we identified an RGC lineage that is intrinsically specified to generate only upper-layer neurons, independently of niche and birthdate. Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: American Association for the Advancement of Science
ISSN: 0036-8075
Last Modified: 04 Jun 2017 08:01
URI: http://orca.cf.ac.uk/id/eprint/71770

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