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Efficacy of a paracetamol and caffeine combination in the treatment of the key symptoms of primary dysmenorrhoea

Ali, Z., Burnett, I., Eccles, Ronald, North, M., Jawad, Moutaz, Jawad, S., Clarke, G. and Milsom, I. 2007. Efficacy of a paracetamol and caffeine combination in the treatment of the key symptoms of primary dysmenorrhoea. Current Medical Research and Opinion 23 (4) , pp. 841-851. 10.1185/030079907X182239

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Objective: Primary dysmenorrhoea is characterised by pain, cramping and backache at the time of menses. Despite the high prevalence of dysmenorrhoea, few sufficiently powered, placebo-controlled studies have examined the efficacy of over the counter analgesics in this condition. Furthermore, even fewer studies have directly examined the efficacy of analgesics on specific dysmenorrhoea symptoms. Research design and main outcome measures: This was a single-dose, placebo-controlled, double blind, crossover study carried out in 320 women with moderate-to-severe dysmenorrhoea pain. At 2 h following dosing, 1 g paracetamol plus 130 mg caffeine led to significantly greater pain relief compared to 1 g paracetamol alone ( p < 0.05), 130 mg caffeine alone ( p < 0.01) or placebo ( p < 0.01). The combination was also significantly more effective in relieving abdominal cramping and backache compared to the other treatment arms. No major treatment related adverse events were reported during this study. Conclusions: When taken at recommended doses, both paracetamol and the combination of paracetamol and caffeine are safe and effective treatments for primary dysmenorrhoea. Consistent with results from other acute pain states, caffeine acts as an analgesic adjuvant and enhances the efficacy of paracetamol. Read More:

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Subjects: R Medicine > RM Therapeutics. Pharmacology
Publisher: Informa Healthcare
ISSN: 0300-7995
Last Modified: 28 Jun 2019 03:21

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