GABAB receptors regulate extrasynaptic GABAa receptors

Connelly, William M., Fyson, Sean J., Errington, Adam Clarke, McCafferty, Cian P., Cope, David W., Di Giovanni, G. and Crunelli, Vincenzo 2013. GABAB receptors regulate extrasynaptic GABAa receptors. Journal of Neuroscience 33 (9) , pp. 3780-3785. 10.1523/JNEUROSCI.4989-12.2013

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Abstract

Tonic inhibitory GABAA receptor-mediated currents are observed in numerous cell types in the CNS, including thalamocortical neurons of the ventrobasal thalamus, dentate gyrus granule cells, and cerebellar granule cells. Here we show that in rat brain slices, activation of postsynaptic GABAB receptors enhances the magnitude of the tonic GABAA current recorded in these cell types via a pathway involving Gi/o G proteins, adenylate cyclase, and cAMP-dependent protein kinase. Using a combination of pharmacology and knockout mice, we show that this pathway is independent of potassium channels or GABA transporters. Furthermore, the enhancement in tonic current is sufficient to significantly alter the excitability of thalamocortical neurons. These results demonstrate for the first time a postsynaptic crosstalk between GABAB and GABAA receptors.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences Neuroscience and Mental Health Research Institute (NMHRI) Medicine
Subjects:	Q Science > QR Microbiology
Publisher:	Society for Neuroscience
ISSN:	0270-6474
Last Modified:	08 May 2019 01:57
URI:	http://orca.cf.ac.uk/id/eprint/72636

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