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ADHD severity is associated with white matter microstructure in the subgenual cingulum

Cooper, Miriam, Thapar, Anita and Jones, Derek K. 2015. ADHD severity is associated with white matter microstructure in the subgenual cingulum. NeuroImage: Clinical 7 , pp. 653-660. 10.1016/j.nicl.2015.02.012

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Abstract

This analysis examined hypothesised associations between microstructural attributes in specific white matter (WM) tracts selected a priori and measures of clinical variability in adolescents with a diagnosis of attention deficit hyperactivity disorder (ADHD). Firstly, associations were explored between WM microstructure and ADHD severity in the subgenual cingulum. Secondly, to ensure that tract-specific approaches afforded enhanced rather than differential sensitivity, associations were measured between WM microstructure and autistic traits in the right corticospinal tract based on results of a previously-published voxelwise analysis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Cardiff University Brain Research Imaging Centre (CUBRIC)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Uncontrolled Keywords: Attention deficit hyperactivity disorder (ADHD); Autism spectrum disorder (ASD); Diffusion MRI; White matter; Spherical deconvolution; Tractography
Publisher: Elsevier
ISSN: 2213-1582
Funders: Wellcome Trust
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 22 February 2015
Last Modified: 22 Dec 2017 19:59
URI: http://orca.cf.ac.uk/id/eprint/72922

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