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Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders

Newland, Benjamin, Newland, Heike, Werner, Carsten, Rosser, Anne Elizabeth and Wang, Wenxian 2015. Prospects for polymer therapeutics in Parkinson's disease and other neurodegenerative disorders. Progress in Polymer Science 44 , pp. 79-112. 10.1016/j.progpolymsci.2014.12.002

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Abstract

Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons and represents a growing health burden to western societies. Like many neurodegenerative disorders the cause is unknown, however, as the pathogenesis becomes ever more elucidated, it is becoming clear that effective delivery is a key issue for new therapeutics. The versatility of today's polymerization techniques allows the synthesis of a wide range of polymer materials which hold great potential to aid in the delivery of small molecules, proteins, genetic material or cells. In this review, we capture the recent advances in polymer based therapeutics of the central nervous system (CNS). We place the advances in historical context and, furthermore, provide future prospects in line with newly discovered advancements in the understanding of PD and other neurodegenerative disorders. This review provides researchers in the field of polymer chemistry and materials science an up-to-date understanding of the requirements placed upon materials designed for use in the CNS aiding the focus of polymer therapeutic design.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Pharmacy
Subjects: R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords: Controlled release; Growth factors; Gene delivery; Transfection; Cell therapies; Drug delivery
Publisher: Elsevier
ISSN: 0079-6700
Date of First Compliant Deposit: 31 October 2017
Date of Acceptance: 16 December 2014
Last Modified: 27 Jun 2019 13:42
URI: http://orca.cf.ac.uk/id/eprint/73255

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