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Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study

Morgan, Kelly, Rahman, M., Atkinson, M., Zhou, S. M., Hill, R., Khanom, A., Paranjothy, S. and Brophy, S. 2013. Association of diabetes in pregnancy with child weight at birth, age 12 months and 5 years--a population-based electronic cohort study. Plos One 8 (11) , e79803. 10.1371/journal.pone.0079803

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Abstract

BACKGROUND:This study examines the effect of diabetes in pregnancy on offspring weight at birth and ages 1 and 5 years. METHODS:A population-based electronic cohort study using routinely collected linked healthcare data. Electronic medical records provided maternal diabetes status and offspring weight at birth and ages 1 and 5 years (n = 147,773 mother child pairs). Logistic regression models were used to obtain odds ratios to describe the association between maternal diabetes status and offspring size, adjusted for maternal pre-pregnancy weight, age and smoking status. FINDINGS:We identified 1,250 (0.9%) pregnancies with existing diabetes (27.8% with type 1 diabetes), 1,358 with gestational diabetes (0.9%) and 635 (0.4%) who developed diabetes post-pregnancy. Children whose mothers had existing diabetes were less likely to be large at 12 months (OR: 0.7 (95%CI: 0.6, 0.8)) than those without diabetes. Maternal diabetes was associated with high weight at age 5 years in children whose mothers had a high pre-pregnancy weight tertile (gestational diabetes, (OR:2.1 (95%CI:1.25-3.6)), existing diabetes (OR:1.3 (95%CI:1.0 to 1.6)). CONCLUSION:The prevention of childhood obesity should focus on mothers with diabetes with a high maternal pre-pregnancy weight. We found little evidence that diabetes in pregnancy leads to long term obesity 'programming'.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Development and Evaluation of Complex Interventions for Public Health Improvement (DECIPHer)
Social Sciences (Includes Criminology and Education)
Additional Information: Pdf uploaded in accordance with publisher's policies at http://www.sherpa.ac.uk/romeo/issn/1932-6203/ (accessed 22.5.15).
Publisher: Public Library of Science
ISSN: 1932-6203
Date of First Compliant Deposit: 30 March 2016
Last Modified: 04 Jun 2017 08:08
URI: http://orca.cf.ac.uk/id/eprint/73452

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