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Oxidized PLs and vascular inflammation

Aldrovandi, Maceler and O'Donnell, Valerie Bridget 2013. Oxidized PLs and vascular inflammation. Current Atherosclerosis Reports 15 (5) , pp. 1989-1996. 10.1007/s11883-013-0323-y

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Abstract

Oxidized PLs (OxPLs) generated in health and disease are now recognized as important mediators of cellular signalling. There is an increasing body of evidence showing that PL peroxidation is not only increased in vascular disorders, but is also a physiological event of relevance to coagulation, innate immunity, and self-tolerance. Nonenzymatically formed OxPLs generated during chronic inflammation is an uncontrolled event, generating hundreds of diverse structures, and prone to more deleterious bioactivities. In contrast, enzymatic formation of OxPLs is tightly regulated, involving receptors and intracellular signaling, acting as part of the normal physiological response to injury in order to restore homeostasis. In the present review, the major nonenzymatic OxPLs structures found during vascular inflammation are summarized, along with a brief description of their known biological activities. Also, we review what is currently known about enzymatic formation of OxPLs by acutely activated immune cells and their signaling actions under homeostatic and pathological conditions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
Uncontrolled Keywords: Oxidized PL;
Publisher: Springer Verlag
ISSN: 1523-3804
Last Modified: 22 Dec 2017 20:11
URI: http://orca.cf.ac.uk/id/eprint/73627

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