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Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction

Pertusati, Fabrizio and McGuigan, Christopher 2015. Diastereoselective synthesis of P-chirogenic phosphoramidate prodrugs of nucleoside analogues (ProTides) via copper catalysed reaction. Chemical Communications 51 (38) , pp. 8070-8073. 10.1039/C5CC00448A

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Abstract

The first copper-catalysed diastereoselective synthesis of P-chiral phosphoramidate prodrugs (ProTides) is reported. This procedure allows the synthesis of diastereomeric-enriched mixtures of ProTides. Application of this methodology to the asymmetric phosphorylation of purine and pyrimidine nucleoside analogues is presented.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Systems Immunity Research Institute (SIURI)
Subjects: Q Science > QD Chemistry
R Medicine > RM Therapeutics. Pharmacology
Publisher: Royal Society of Chemistry
ISSN: 1359-7345
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 2 April 2015
Last Modified: 29 Jan 2020 14:15
URI: http://orca.cf.ac.uk/id/eprint/73659

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