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Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis

Frugtniet, Bethan, Jiang, Wen Guo and Martin, Tracey Amanda 2015. Role of the WASP and WAVE family proteins in breast cancer invasion and metastasis. Breast Cancer: Targets and Therapy 2015 (7) , pp. 99-109. 10.2147/BCTT.S59006

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Abstract

The Wiskott–Aldrich syndrome protein (WASP) and WASP family verprolin-homologous protein (WAVE) family are a group of molecules that form a key link between GTPases and the actin cytoskeleton. The role of WASP/WAVE family proteins in the control of actin polymerization through activation of the actin-related protein 2/3 complex is critical in the formation of the actin-based membrane protrusions seen in cell migration and invasion. For this reason, the activity of the WASP/WAVE family in cancer cell invasion and migration has been of great interest in recent years. Many reports have highlighted the potential of targeting the WASP/WAVE family as a therapy for the prevention of cancer progression, in particular breast cancer. This review focuses on the role of the WASP/WAVE family in breast cancer cell invasion and migration and how this relates to the molecular mechanisms of WASP/WAVE activity, their exact contributions to the stages of cancer progression, and how this can lead to the development of anticancer drugs that target the WASP/WAVE family and related pathways.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Dove Medical Press
ISSN: 1179-1314
Date of Acceptance: 23 January 2015
Last Modified: 14 Mar 2019 14:45
URI: http://orca.cf.ac.uk/id/eprint/73673

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