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Diagnosis of toxoplasmosis using a synthetic glycosylphosphatidylinositol glycan

Götze, Sebastian, Azzouz, Nahid, Tsai, Yu-Hsuan, Groß, Uwe, Reinhardt, Anika, Anish, Chakkumkal, Seeberger, Peter H. and Varón?Silva, Daniel 2014. Diagnosis of toxoplasmosis using a synthetic glycosylphosphatidylinositol glycan. Angewandte Chemie - International Edition 53 (50) , pp. 13701-13705. 10.1002/anie.201406706

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Abstract

Around 2 billion people worldwide are infected with the apicomplexan parasite Toxoplasma gondii which induces a variety of medical conditions. For example, primary infection during pregnancy can result in fetal death or mental retardation of the child. Diagnosis of acute infections in pregnant women is challenging but crucially important as the drugs used to treat T. gondii infections are potentially harmful to the unborn child. Better, faster, more reliable, and cheaper means of diagnosis by using defined antigens for accurate serological tests are highly desirable. Synthetic pathogen-specific glycosylphosphatidylinositol (GPI) glycan antigens are diagnostic markers and have been used to distinguish between toxoplasmosis disease states using human sera.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: Wiley-Blackwell
ISSN: 1433-7851
Last Modified: 21 Feb 2019 15:04
URI: http://orca.cf.ac.uk/id/eprint/73722

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