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Molecular analysis of carbohydrate−antibody interactions: case study using a bacillus anthracis tetrasaccharide

Oberli, Matthias A., Tamborrini, Marco, Tsai, Yu-Hsuan, Werz, Daniel B., Horlacher, Tim, Adibekian, Alexander, Gauss, Dominik, Mo?ller, Heiko M., Pluschke, Gerd and Seeberger, Peter H. 2010. Molecular analysis of carbohydrate−antibody interactions: case study using a bacillus anthracis tetrasaccharide. Journal of the American Chemical Society 132 (30) , pp. 10239-10241. 10.1021/ja104027w

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Abstract

The process for selecting potent and effective carbohydrate antigens is not well-established. A combination of synthetic glycan microarray screening, surface plasmon resonance analysis, and saturation transfer difference NMR spectroscopy was used to dissect the antibody-binding surface of a carbohydrate antigen, revealing crucial binding elements with atomic-level detail. This analysis takes the first step toward uncovering the rules for structure-based design of carbohydrate antigens.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: American Chemical Society
ISSN: 0002-7863
Last Modified: 04 Jun 2017 08:10
URI: http://orca.cf.ac.uk/id/eprint/73728

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