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Novel olfactory ligands via terpene synthases

Touchet, Sabrina, Chamberlain, Keith, Woodcock, Christine M., Miller, David James, Birkett, Michael A., Pickett, John and Allemann, Rudolf Konrad 2015. Novel olfactory ligands via terpene synthases. Chemical Communications 51 (35) , pp. 7550-7553. 10.1039/C5CC01814E

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Abstract

A synthetic biology approach to the rational design of analogues of olfactory ligands by providing unnatural substrates for the enzyme synthesising (S)-germacrene D, an olfactory ligand acting as a plant derived insect repellent, to produce novel ligands is described as a viable alternative to largely unsuccessful ligand docking studies. (S)-14,15-Dimethylgermacrene D shows an unexpected reversal in behavioural activity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Subjects: Q Science > QD Chemistry
Publisher: RSC Publishing
ISSN: 1359-7345
Funders: BBSRC
Date of First Compliant Deposit: 30 March 2016
Date of Acceptance: 30 March 2015
Last Modified: 22 Nov 2017 11:19
URI: http://orca.cf.ac.uk/id/eprint/73825

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