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Human leukocyte antigen-associated drug hypersensitivity [review]

Illing, P. T., Vivan, J. P., Rossjohn, Jamie and McCluskey, J. 2013. Human leukocyte antigen-associated drug hypersensitivity [review]. Current Opinion in Immunology 25 (1) , pp. 81-89. 10.1016/j.coi.2012.10.002

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A growing number of associations between adverse drug reactions and alleles of the human leukocyte antigen (HLA) genes are now known. Although several models have been proposed to explain these associations, an underlying molecular basis has only recently been described. The associations between HLA-B*57:01 and abacavir hypersensitivity syndrome, and HLA-B*15:02 and carbamazepine-induced bullous skin disease have provided new insights into the mechanism associated with hypersensitivity reactions to these drugs. Here we discuss recent evidence that small molecules can interact with specific HLA to distort self-peptide presentation leading to autoimmune-like drug hypersensitivities that potentially provide clues to the mechanisms underlying other immunopathologies.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Systems Immunity Research Institute (SIURI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: abacavir;carbamazepine;HLA antigen;HLA B44 antigen;HLA B57 antigen antigen binding;antigen function;antigen presentation;antigen recognition;antigenicity; autoimmunity;drug DNA interaction;drug hypersensitivity; gene;gene function;genetic association;genetic polymorphism;HLA system;human;Human immunodeficiency virus 1 infection;human leukocyte antigen gene; immunopathogenesis;immunostimulation;maculopapular rash; protein expression;protein processing;review;skin manifestation;Stevens Johnson syndrome;toxic epidermal necrolysis Animals; Anti-HIV Agents; Anticonvulsants; Antigen Presentation; Autoantigens; Carbamazepine; Dideoxynucleosides; Drug Hypersensitivity; HIV Infections; HLA Antigens;Humans;Peptide Fragments;Protein Binding; Seizures;Skin
Additional Information: Chemicals and CAS Registry Numbers: abacavir, 136470-78-5, 188062-50-2; carbamazepine, 298-46-4, 8047-84-5;Anti-HIV Agents; Anticonvulsants; Autoantigens; Carbamazepine, 298-46-4; Dideoxynucleosides; HLA Antigens; Peptide Fragments; abacavir, WR2TIP26VS
Publisher: Elsevier
ISSN: 0952-7915
Last Modified: 04 Jun 2017 08:11

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