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Schizophrenia genetics: emerging themes for a complex disorder

Kavanagh, D., Tansey, Katherine, O'Donovan, Michael Conlon and Owen, Michael John 2015. Schizophrenia genetics: emerging themes for a complex disorder. Molecular Psychiatry 20 (1) , pp. 72-76. 10.1038/mp.2014.148

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Abstract

After two decades of frustration, genetic studies of schizophrenia have entered an era of spectacular success. Advances in genotyping technologies and high throughput sequencing, increasing analytic rigour and collaborative efforts on a global scale have generated a profusion of new findings. The broad conclusions from these studies are threefold: (1) schizophrenia is a highly polygenic disorder with a complex array of contributing risk loci across the allelic frequency spectrum; (2) many psychiatric illnesses share risk genes and alleles, specifically, schizophrenia has substantial overlaps with bipolar disorder, intellectual disability, major depressive disorder and autism spectrum disorders; and (3) some convergent biological themes are emerging from studies of schizophrenia and related disorders. In this commentary, we focus on the very recent findings that have emerged in the past 12 months, and in particular, the areas of convergence that are beginning to emerge from multiple study designs.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Nature Publishing Group
ISSN: 1359-4184
Last Modified: 20 Mar 2019 23:54
URI: http://orca.cf.ac.uk/id/eprint/74807

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Cited 8 times in Web of Science. View in Web of Science.

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