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Longitudinal associations between adolescent psychotic experiences and depressive symptoms

Sullivan, Sarah A., Wiles, Nicola, Kounali, Daphne, Lewis, Glyn, Heron, Jon, Cannon, Mary, Mahedy, Liam, Jones, Peter B., Stochl, Jan and Zammit, Stanley 2014. Longitudinal associations between adolescent psychotic experiences and depressive symptoms. PLoS ONE 9 (8) , e105758. 10.1371/journal.pone.0105758

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Abstract

BACKGROUND: Psychotic experiences are prevalent in community samples and are highly correlated with depressive symptoms. This study aimed to investigate the longitudinal associations between psychotic experiences and depressive symptoms between adolescence and young adulthood. METHOD: Prospective cohort study with a 6 year follow-up in a community sample of 7632 adolescents and young adults. Depressive symptoms were assessed with the Short Moods and Feelings Questionnaire and psychotic experiences with a semi-structured clinical interview at 12 and 18 years. Longitudinal and cross-sectional associations were investigated with regression and structural equation models. RESULTS: Depressive symptoms and psychotic experiences were associated at each time-point (12 years r = 0.486 [95% CI 0.457, 0.515]; 18 years r = 0.286 [95% CI 0.233, 0.339]) and there were longitudinal within-phenotype associations (depressive symptoms r = 0.252 [95% CI 0.205, 0.299]; psychotic experiences r = 0.662 [95% CI 0.595, 0.729]). There was an across-phenotype association between psychotic experiences at 12 and depressive symptoms at 18 r = 0.139 [95% CI 0.086, 0.192; p<0.001], but no association between depressive symptoms at 12 and psychotic experiences at 18 r = -0.022 [95% CI -0.032, 0.077; p = 0.891]. CONCLUSIONS: Longitudinal across-phenotype associations were substantially weaker than cross-sectional associations or within-phenotype longitudinal associations. Whilst psychotic experiences at 12 years were associated with a small increase in depression at 18 years, depression at 12 years was not associated with psychotic experiences at 18 years once across-phenotype cross-sectional and within-phenotype longitudinal associations were accounted for. This suggests that the biological mechanisms underlying depression at this age do not increase subsequent risk of psychotic experiences once they resolve.

Item Type: Article
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics
Medicine
Subjects: R Medicine > R Medicine (General)
Additional Information: Copyright: © 2014 Sullivan et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Publisher: Public Library of Science
ISSN: 1932-6203
Last Modified: 25 Jul 2017 04:02
URI: http://orca.cf.ac.uk/id/eprint/74839

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Cited 4 times in Web of Science. View in Web of Science.

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