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The emerging roles of TCF4 in disease and development

Forrest, Marc, Hill, Matthew J., Quantock, Andrew James, Martin-Rendon, Enca and Blake, Derek J. 2014. The emerging roles of TCF4 in disease and development. Trends in Molecular Medicine 20 (6) , pp. 322-331. 10.1016/j.molmed.2014.01.010

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Abstract

Genome-wide association studies have identified common variants in transcription factor 4 (TCF4) as susceptibility loci for schizophrenia, Fuchs’ endothelial corneal dystrophy, and primary sclerosing cholangitis. By contrast, rare TCF4 mutations cause Pitt–Hopkins syndrome, a disorder characterized by intellectual disability and developmental delay, and have also been described in patients with other neurodevelopmental disorders. TCF4 therefore sits at the nexus between common and rare disorders. TCF4 interacts with other basic helix–loop–helix proteins, forming transcriptional networks that regulate the differentiation of several distinct cell types. Here, we review the role of TCF4 in these seemingly diverse disorders and discuss recent data implicating TCF4 as an important regulator of neurodevelopment and epithelial–mesenchymal transition.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Optometry and Vision Sciences
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RE Ophthalmology
Publisher: Elsevier
ISSN: 1471-4914
Last Modified: 14 Mar 2019 12:29
URI: http://orca.cf.ac.uk/id/eprint/74970

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