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The inflammatory cytokines: molecular biomarkers for major depressive disorder?

Martin, Charlotte, Tansey, Katherine, Schalkwyk, Leonard C. and Powell, Timothy R. 2014. The inflammatory cytokines: molecular biomarkers for major depressive disorder? Biomarkers in Medicine 9 (2) , pp. 169-180. 10.2217/bmm.14.29

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Abstract

Cytokines are pleotropic cell signaling proteins that, in addition to their role as inflammatory mediators, also affect neurotransmitter systems, brain functionality and mood. Here we explore the potential utility of cytokine biomarkers for major depressive disorder. Specifically, we explore how genetic, transcriptomic and proteomic information relating to the cytokines might act as biomarkers, aiding clinical diagnosis and treatment selection processes. We advise future studies to investigate whether cytokine biomarkers might differentiate major depressive disorder patients from other patient groups with overlapping clinical characteristics. Furthermore, we invite future pharmacogenetic studies to investigate whether early antidepressant-induced changes to cytokine mRNA or protein levels precede behavioral changes and act as longer-term predictors of clinical antidepressant response.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Publisher: Future Medicine
ISSN: 1752-0363
Last Modified: 14 Mar 2019 11:38
URI: http://orca.cf.ac.uk/id/eprint/75003

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Cited 16 times in Scopus. View in Scopus. Powered By Scopus® Data

Cited 2 times in Web of Science. View in Web of Science.

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