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Long term cardiovascular consequences of chronic lung disease of prematurity

Poon, Chuen, Edwards, Martin and Kotecha, Sailesh 2013. Long term cardiovascular consequences of chronic lung disease of prematurity. Paediatric Respiratory Reviews 14 (4) , pp. 242-249. 10.1016/j.prrv.2012.08.003

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Abstract

Pulmonary arterial (PA) hypertension in preterm infant is an important consequence of chronic lung disease of prematurity (CLD) arising mainly due to impaired alveolar development and dysregulated angiogenesis of the pulmonary circulation. Although PA pressure and resistance in these children normalise by school age, their pulmonary vasculature remains hyper-reactive to hypoxia until early childhood. Furthermore, there is evidence that systemic blood pressure in preterm born children with or without CLD is mildly increased at school age and in young adulthood when compared to term-born children. Arterial stiffness may be increased in CLD survivors due to increased smooth muscle tone of the pre-resistance and resistance vessels rather than the loss of elasticity in the large arteries. This review explores the long term effects of CLD on the pulmonary and systemic circulations along with their clinical correlates and therapeutic approaches.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RJ Pediatrics
Uncontrolled Keywords: Bronchopulmonary dysplasia; Chronic lung disease of prematurity; Arterial hypertension; Pulmonary arterial hypertension; Arterial stiffness; Lung development
Publisher: Elsevier
ISSN: 1526-0542
Last Modified: 30 Jun 2017 03:58
URI: http://orca.cf.ac.uk/id/eprint/75141

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