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Verbal episodic memory deficits in remitted bipolar patients: A combined behavioural and fMRI study

Oertel-Knöchel, Viola, Reinke, Britta, Feddern, Richard, Knake, Annika, Knöchel, Christian, Prvulovic, David, Fußer, Fabian, Karakaya, Tarik, Loellgen, Deborah, Freitag, Christine, Pantel, Johannes and Linden, David Edmund Johannes 2013. Verbal episodic memory deficits in remitted bipolar patients: A combined behavioural and fMRI study. Journal of Affective Disorders 150 (2) , pp. 430-440. 10.1016/j.jad.2013.04.036

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Background Episodic memory deficits affect the majority of patients with bipolar disorder (BD). Aims The study investigates episodic memory performance through different approaches, including behavioural measures, physiological parameters, and the underlying functional activation patterns with functional neuroimaging (fMRI). Methods 26 Remitted BD patients and a matched group of healthy controls underwent a verbal episodic memory test together with monitored autonomic response, psychopathological ratings and functional magnetic resonance imaging (fMRI) during the verbal episodic memory test. Results Compared to healthy controls, BD patients performed significantly worse during the episodic memory task. The results further indicate that verbal episodic memory deficits in BD are associated with abnormal functional activity patterns in frontal, occipital and limbic regions, and an increase in stress parameters. Limitations We aimed to minimise sample heterogeneity by setting clear criteria for remission, based on the scores of a depression (BDI II) and mania scale (BRMAS) and on the DSM IV criteria. However, our patients were not symptom-free and scored higher on BDI II scores than the control group. Conclusions The results are of interest for the treatment of cognitive symptoms in BD patients, as persistent cognitive impairment may hamper full rehabilitation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
R Medicine > RZ Other systems of medicine
Uncontrolled Keywords: Adult; Bipolar Disorder; Cognition Disorders; Female; Humans; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Episodic; Middle Aged; Neuropsychological Tests
Publisher: Elsevier
ISSN: 0165-0327
Last Modified: 04 Jun 2017 08:16

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