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Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis

Hull, James H., Garrod, Rachel, Ho, Timothy B., Knight, Ronald K., Cockcroft, John Ronald, Shale, D and Bolton, Charlotte E. 2013. Dynamic vascular changes following intravenous antibiotics in patients with cystic fibrosis. Journal of Cystic Fibrosis 12 (2) , pp. 125-129. 10.1016/j.jcf.2012.07.004

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Background: Adults with cystic fibrosis (CF) have altered large artery haemodynamics which is associated with a persisting systemic inflammatory state. We hypothesized that a short-term intervention favorably influencing the inflammatory status may modify their haemodynamic state. Methods: Adult patients with CF were studied immediately preceding and following 2. weeks of intravenous antibiotics. Large artery haemodynamics, principally heart rate-adjusted augmentation index (AIx) were obtained. Blood pressure (BP), spirometry and CRP were also measured. Results: Complete data was available for 15 patients; mean (SD) age 28 (6)years. CRP was reduced while FEV1% predicted improved. Following treatment AIx was lower: 10.9 (10.9)% to 8.1 (10.9)% (p<0.05) while BP was similar and a trend toward lower heart rate (p=0.06). Change in AIx was related to baseline FEV1% predicted (r=0.77) and BMI (r=0.71) (both P<0.01). Conclusion: The abnormal central haemodynamics evident in adults with CF is modulated with a short intervention of intravenous antibiotics.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
Publisher: Elsevier
ISSN: 1569-1993
Date of Acceptance: 5 July 2012
Last Modified: 04 Jun 2017 08:17

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