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Regulation of TRPML1 function

Waller-Evans, Helen and Lloyd-Evans, Emyr 2015. Regulation of TRPML1 function. Biochemical Society Transactions 43 (3) , pp. 442-446. 10.1042/BST20140311

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Abstract

TRPML1 is a ubiquitously expressed cation channel found on lysosomes and late endosomes. Mutations in TRPML1 cause mucolipidosis type IV and it has been implicated in Alzheimer's disease and HIV. However, the mechanisms by which TRPML1 activity is regulated are not well understood. This review summarizes the current understanding of TRPML1 activation and regulation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Portland Press
ISSN: 0300-5127
Last Modified: 04 Jun 2017 08:17
URI: http://orca.cf.ac.uk/id/eprint/75303

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