Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The relationship between variation in genes, GABA, structure and gamma oscillations in the visual and auditory system of healthy individuals and psychiatric disorder

Brealy, Jennifer 2015. The relationship between variation in genes, GABA, structure and gamma oscillations in the visual and auditory system of healthy individuals and psychiatric disorder. PhD Thesis, Cardiff University.
Item availability restricted.

[img]
Preview
PDF - Accepted Post-Print Version
Download (1MB) | Preview
[img] PDF - Supplemental Material
Restricted to Repository staff only

Download (645kB)

Abstract

Visual perception is highly variable across healthy individuals and increasing evidence suggests that this inter-individual variation could be due to differences at the genetic, neurochemical, structural and neurophysiological level. Specifically, variation in the GAD1 gene (responsible for synthesising the majority of cortical GABA) has been associated with differences in the level of the inhibitory neurotransmitter GABA. In addition, differences in GABA and cortical structural parameters (surface area and thickness) have been shown to predict differences in neural gamma oscillations. However, these findings have not been replicated in large independent studies. Hence, Chapter 3 and 4 of this thesis combines the non-invasive neuroimaging tools MRI, MRS and MEG with genetic data to investigate the relationship between variations in genes, GABA, structure and gamma oscillations in the visual cortex of a large cohort of healthy individuals. Group differences in GABA, structure and gamma oscillations have also been reported between psychiatric populations (schizophrenia and bipolar disorder) and healthy individuals.However, differences in the direction of effect (increase or decrease) and no group differences have been found. Thus, Chapter 5 aims to further study these inconsistent findings by exploring group differences in GABA, structure and gamma oscillations between a healthy group and a schizoaffective bipolar disorder group. Lastly, inter- individual variation is also present in auditory perception but has received much less attention into the factors driving this variation. As in the visual system, similar links between neurochemical, structural and neurophysiological measures could be present in the auditory domain. Chapter 6 investigates the association between auditory gamma oscillations and auditory structural parameters in a healthy cohort.

Item Type: Thesis (PhD)
Status: Unpublished
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Subjects: Q Science > QH Natural history > QH426 Genetics
R Medicine > RC Internal medicine > RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
Date of First Compliant Deposit: 30 March 2016
Last Modified: 15 Oct 2016 04:25
URI: http://orca.cf.ac.uk/id/eprint/75463

Actions (repository staff only)

Edit Item Edit Item