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The ENCODE project: implications for psychiatric genetics

Kavanagh, Davd, Dwyer, Sarah, O'Donovan, Michael Conlon and Owen, Michael John 2013. The ENCODE project: implications for psychiatric genetics. Molecular Psychiatry 18 (5) , pp. 540-542. 10.1038/mp.2013.13

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Abstract

The ENCyclopedia Of DNA Elements (ENCODE) project is a public research consortium that aims to identify all functional elements of the human genome sequence. The project comprised 1640 data sets, from 147 different cell type and the findings were released in a coordinated set of 34 publications across several journals. The ENCODE publications report that 80.4% of the human genome displays some functionality. These data have important implications for interpreting results from large-scale genetics studies. We reviewed some of the key findings from the ENCODE publications and discuss how they can influence or inform further investigations into the genetic factors contributing to neuropsychiatric disorders.

Item Type: Article
Status: Published
Schools: Medicine
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Neuroscience and Mental Health Research Institute (NMHRI)
Subjects: R Medicine > R Medicine (General)
Publisher: Nature Publishing Group
ISSN: 1359-4184
Last Modified: 04 Jun 2017 08:19
URI: http://orca.cf.ac.uk/id/eprint/75768

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