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KIAA1199 and its biological role in human cancer and cancer cells (review)

Zhang, Yongsheng, Jia, Shuqin and Jiang, Wen Guo 2014. KIAA1199 and its biological role in human cancer and cancer cells (review). Oncology Reports 31 (4) , pp. 1503-1508. 10.3892/or.2014.3038

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Abstract

KIAA1199 is a gene included in the Human Unidentified Gene-Encoded (HUGE) large protein database which contains more than 2,400 members identified in the Kazusa cDNA sequencing project. Early studies described KIAA1199 as an inner ear-specific protein in which 3 point mutations were found to be associated with non‑syndromic hearing loss. Recently, KIAA1199 has been found to play a central role in hyaluronan binding and depolymerisation, and a small number of studies indicate its senescence/apoptosis-promoting role. An increasing body of evidence suggests its involvement in cancer progression, metastasis and poor prognosis of patients with cancer as determined in clinical studies. It has also been shown, in vitro, that KIAA1199 influences the proliferation, adhesion, motility, invasiveness and epithelial-to-mesenchymal transition of cancer cells. Pathway signalling analysis found that KIAA1199 is a likely target gene of the Wnt/β-catenin signalling pathway. Therefore, KIAA1199 may be a new and prospective target for cancer therapy, although further in vitro and in vivo investigations are required.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Subjects: R Medicine > R Medicine (General)
R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer)
Publisher: Spandidos Publications
ISSN: 1021-335X
Related URLs:
Date of Acceptance: 24 January 2014
Last Modified: 19 Jul 2017 12:39
URI: http://orca.cf.ac.uk/id/eprint/75803

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